Category heptane

n-Heptane Overview

n-Heptane (CAS No. 142-82-5, EC No. 205-563-8) is a straight-chain hydrocarbon (C₇H₁₆) recognized throughout the European regulatory framework as a key industrial solvent. It is classified under the CLP Regulation Annex VI and officially registered in ECHA’s Registered Substances Database, confirming its full REACH compliance for import and use across the European Economic Area (EEA) at volumes exceeding 1,000 tonnes per year.

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Substance Names and Other Identifiers

Main substance name:

• n-Heptane

Other common names and synonyms:

• Heptane
• Heptan
• Heptanen
• Dipropylmethane
• Dipropyl methane
• Heptyl hydride
• Normal heptane
• Heptane (all isomers)
• Heptane [99.0% for HPLC Solvent]
• Heptane [and isomers]
• n-Heptano
• Gettysolve-C
• Skellysolve C
• Eptani
• Hydrocarbon solvents

Regulatory process names:

• Heptane
• Heptane; n-Heptane
• n-Heptane
• heptane/n-heptane

Translated names (examples):

• Heptan, n-Heptan (German)
• Heptan, N-heptan (Romanian)

Trade names:

• Heptane
• n-Heptane

Identifiers:

• CAS number: 142-82-5
• EC number: 205-563-8
• Index number: 601-008-00-2
• Other CAS numbers (legacy or related): 44607-13-8, 8031-33-2

IUPAC names:

• Dipropylmethane
• n-Heptane

Regulatory and Directive references:
n-Heptane is listed under multiple EU regulations and directives, including:

General Product Safety Regulation – Hazardous Substances

REACH Registration Dossier

EC Inventory

C&L Inventory

Pre-registration process

Aerosols Directive – Flammable Contents

Chemical Agents Directive (CAD) – Hazardous Agents

Ambient Air Quality Directive, Annex X – Ozone Precursor Substances

Occupational Exposure Limits (OELVs) – Indicative List

Construction Products Regulation – Hazardous Substances (Annex I & Art. 6)

EU Ecolabel Regulation – Hazardous Substance Restrictions

Medical Devices Directives and Regulations – Hazardous Substances

Pressure Equipment Directive – Group 1 Fluids

Waste Framework Directive – Annex III Hazardous Properties

Fertiliser Regulation, Annex I, E.3 – Chelating/Complexing Agents

Due to its extensive industrial and scientific use, n-Heptane is known under a wide range of regulatory, IUPAC, and trade names across different European legislations and databases.

Regulatory Process Names:
Dipropyl Methane, Eptani, Gettysolve-C, Heptan, Heptane, Heptanen, Heptyl Hydride, n-Heptane, Skellysolve C

Translated Names (EU languages):

• Heptan / n-Heptan (DE) – German
• Heptan / N-heptan (RO) – Romanian

IUPAC and Technical Names:
Dipropylmethane, n-Heptane, Heptane (all isomers), Heptane [99.0% for HPLC Solvent], Normal Heptane, Hydrocarbon Solvent

Trade Names:
Heptane, n-Heptane, Gettysolve-C, Skellysolve C

Identifiers:

• CAS Number: 142-82-5 (Main)
• EC Number: 205-563-8
• Index Number (CLP): 601-008-00-2
• Other CAS Numbers: 44607-13-8, 8031-33-2
• Molecular Formula: C₇H₁₆

These identifiers appear consistently across EINECS, C&L Inventory, REACH Pre-registration, and multiple EU regulatory annexes, ensuring full traceability and transparency in supply.

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Regulatory Framework and Compliance

n-Heptane is explicitly listed under numerous European chemical and environmental legislations, highlighting its regulated yet accepted status in industrial and laboratory operations:

• REACH Regulation – Registered substance (≥1000 tpa)
• CLP Regulation Annex VI – Harmonized classification & labeling
• Seveso III Directive Annex I – Industrial accident prevention
• Waste Framework Directive Annex III – Hazardous properties
• Occupational Exposure Limits (OELs) – Indicative EU OELVs
• Construction Products Regulation (Annex I & Art.6(5))
• EU Ecolabels & Environmental Policy Framework Directive
• Medical Devices Regulation / Directive (Hazardous Substances)
• General Product Safety Regulation & Workplace Safety Directive

This extensive inclusion across directives confirms that n-Heptane is both recognized and regulated for controlled industrial use, making it an ideal choice for European manufacturers seeking long-term compliant sourcing.

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Applications Across European Industries

n-Heptane’s versatility has established it as a critical raw material and process solvent in:

• Pharmaceutical manufacturing – extraction, crystallization, and purification
• Laboratories – high-purity analytical use (HPLC, GC)
• Coatings and adhesives – solvent and viscosity control
• Automotive and fuel industry – reference standard for octane rating
• Cleaning and degreasing agents – controlled volatility applications

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Safety and Environmental Management

Classified as a highly flammable liquid (H225), skin irritant (H315), and toxic to aquatic life (H410), n-Heptane must be handled with professional containment, proper labeling, and full compliance to the GHS/CLP system.
Manufacturers provide complete Safety Data Sheets (SDS) and Guidance on Safe Use, aligned with the Chemical Agents Directive (CAD) and Pressure Equipment Directive.

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Why Choose Our n-Heptane

Fully REACH-registered and CLP compliant
High-purity grades (up to 99%) for pharmaceutical and analytical use
Stable European supply in ISO tanks or drums
Complete documentation package (SDS, COA, technical data)
Proven compliance with EU industrial, medical, and environmental standards

Our n-Heptane product line delivers consistency, safety, and full regulatory transparency for European customers in pharmaceuticals, R&D, and specialty chemicals manufacturing.

For technical details, safety classifications, and compliance information, professionals can refer to the European Chemicals Agency (ECHA) official database:
https://echa.europa.eu/substance-information/-/substanceinfo/100.014.194

This authoritative link strengthens data transparency and helps industry experts verify REACH registration status, CLP classification, and exposure limits of n-Heptane (CAS 142-82-5) under European regulatory frameworks.

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Article Content:

For international buyers, one of the most common questions when sourcing n-Heptane is: “Which countries can exporters ship to?” The answer depends on shipping regulations, chemical handling standards, and the exporter’s logistics capabilities.

1. Global Shipping Overview

Most reputable n-Heptane exporters can ship to a wide range of countries, including:

• North America: United States, Canada, Mexico
• Europe: Germany, France, United Kingdom, Italy, Spain, Netherlands
• Asia: China, India, Japan, South Korea, Singapore
• Middle East: UAE, Saudi Arabia, Israel
• Africa: South Africa, Egypt, Morocco

However, shipping is subject to local chemical import regulations and safety compliance requirements.

2. Regulatory Considerations

n-Heptane is classified as a flammable chemical and is subject to international hazardous materials transport regulations, including:

• UN Number: 1208 (for transport of n-Heptane)
• IMDG Code: For sea transport
• IATA Regulations: For air shipment
• Local Import Permits: Some countries require chemical import licenses or safety documentation

Exporters must ensure all shipments meet these standards to avoid delays or legal issues.

3. Packaging and Shipping Methods

n-Heptane is typically shipped in:

• ISO Tanks: For large volumes (16-16.8 MT per tank)
• Drums: Standard 137 kg drums for smaller shipments
• Palletized Containers: For drums only

Proper packaging ensures safety and compliance during transport.

4. Choosing the Right Exporter

A reliable n-Heptane exporter should provide:

• Documentation for international shipping, including SDS, COA, and customs paperwork
• Expertise in handling hazardous chemicals
• Flexible shipping options for multiple countries

Conclusion

n-Heptane exporters can ship to most industrialized and developing countries, but buyers must verify local regulations and import requirements. Partnering with an experienced exporter ensures smooth delivery, regulatory compliance, and safe handling of flammable chemicals.

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Further Reading and References

For more information on international chemical shipping regulations and safety standards, see:

• UN Recommendations on the Transport of Dangerous Goods
• IATA Dangerous Goods Regulations

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When sourcing n-Heptane from international suppliers, one of the most common questions buyers ask is: “What purity levels are available?” The purity of n-Heptane directly impacts its performance, safety, and suitability for various applications, from industrial solvents to pharmaceutical processes.

1. Common Purity Grades of n-Heptane

Suppliers typically offer n-Heptane in the following purity levels:

• 95% Purity: Often used in industrial applications such as adhesives, coatings, and general solvents. Suitable for processes where ultra-high purity is not required.
• 99% Purity: A widely used grade for laboratories, analytical applications, and some industrial uses. It balances cost and performance.
• 99.5% Purity or Higher: High-purity n-Heptane is commonly used in pharmaceutical, electronic, and specialty chemical industries. This grade meets strict quality standards and is often accompanied by Certificates of Analysis (COA).

2. Why Purity Matters

• Industrial Applications: Lower purity grades may contain hydrocarbons that do not affect general solvent performance but are unsuitable for sensitive processes.
• Pharmaceutical & Laboratory Use: Impurities can affect reactions, product stability, or analytical accuracy. High-purity n-Heptane ensures consistency and compliance with regulatory standards.
• Safety & Handling: Suppliers provide Material Safety Data Sheets (MSDS) indicating handling precautions for each grade.

3. How to Verify Purity

Before purchasing, buyers should request:

• COA (Certificate of Analysis): Confirms the exact purity and identifies impurities.
• MSDS (Material Safety Data Sheet): Provides safety and handling information.
• Sample Testing: Some suppliers provide small sample shipments for testing in your own processes.

4. Choosing the Right Supplier

A reliable n-Heptane supplier should provide:

• Clear documentation of purity levels.
• International shipping options with proper packaging (ISO tanks, drums, pallets).
• Compliance with certifications such as REACH, ISO, or GMP when required.

Conclusion

Understanding the purity levels of n-Heptane is critical for selecting the right grade for your application. Always request documentation and, if possible, test samples to ensure you receive the quality you need. Partnering with a reputable supplier ensures safe, consistent, and compliant n-Heptane delivery for industrial, laboratory, or pharmaceutical purposes.

Further Reading and References

For more detailed technical information on n-Heptane purity standards and applications, you can refer to Junyuan Petroleum Group’s n-Heptane Product Page, which provides comprehensive COA, MSDS, and application notes. Additionally, the PubChem database offers extensive chemical properties and safety data, helping buyers make informed decisions.

Junyuan Petroleum Group cordially invites you to join us at CPhI Japan 2026 in Tokyo, where we will present our high-purity n-Heptane solutions designed to empower the global pharmaceutical supply chain.

📅 Event Details

Date: April 21–23, 2026 Location: Tokyo, Japan Scale: Japan’s largest pharmaceutical ingredients exhibition, covering 26,000 sqm, gathering 528 exhibitors and 19,681 professional visitors. Past Data: 400–500 exhibitors (40% domestic, 60% international from China, India, Europe, and the U.S.); 8,000+ professional attendees, including top Japanese pharma companies such as Takeda and Daiichi Sankyo.

Market Opportunities in Japan: High-End Demand Meets n-Heptane Applications

1. Japan’s Pharmaceutical Market Position

The world’s third-largest pharmaceutical market with an API market size of USD 37.2 billion in 2024. Over 70% of high-end APIs rely on imports, with China as a primary supplier. Tokyo hosts the headquarters of industry leaders such as Eisai and Takeda, accounting for more than 40% of Japan’s API market and serving as a hub for R&D and trade in advanced ingredients.

2. Core Applications of n-Heptane in Pharma

Drug Synthesis Solvent: Ideal for extraction, reaction medium, and purification processes, meeting Japan’s stringent pharmaceutical standards. Biopharmaceutical Support: Plays a critical role in mRNA vaccine production and biosimilar development (e.g., anti-PD-1 therapies). Regulatory Advantage: With full REACH certification, n-Heptane helps Japanese firms overcome international trade barriers and aligns with the government’s push for “antibiotic API localization.”

Junyuan Petroleum Group’s n-Heptane Advantages

1. REACH-Certified Compliance

Fully compliant with EU environmental, health, and safety standards. Provides global market access and ensures Japanese customers benefit from a secure and compliant supply chain.

2. Technical Strength & Versatility

High Purity Grades: Suitable for pharmaceutical processes including solvents, extractants, and analytical reagents (HPLC). Broad Applications: Aligns with CPhI Japan’s exhibition scope, covering excipients, stabilizers, nucleic acid purification, and biopharma R&D.

3. Tailored Services for Japan

Customized technical solutions to meet local requirements. Strong support for CDMO collaborations and innovative drug development.

Driving Innovation and Partnerships

At CPhI Japan 2026, Junyuan Petroleum Group will demonstrate how our REACH-certified n-Heptane is more than a solvent — it is a trusted enabler of pharmaceutical innovation, compliance, and international cooperation.

We look forward to building stronger partnerships with Japanese pharmaceutical leaders and contributing to the next wave of global healthcare solutions.

📍 Meet us in Tokyo – April 21–23, 2026.

#Heptane #Pharma #REACH #APIs #Pharmaceuticals #CPhI #Japan #Biopharma #Healthcare

In Germany, the leading pharmaceutical associations ABDA, BAK, DAV, and ADKA organize some of Europe’s most influential trade fairs and congresses. These events bring together the largest annual gatherings of the pharmaceutical market, where industry leaders, policymakers, scientists, and media representatives connect to shape the future of healthcare.

🔹 Exhibition Highlights

Finished pharmaceuticals: OTC, prescription drugs, biopharmaceuticals, TCM, herbal medicines. Active ingredients & intermediates: vitamins, hormones, antibiotics, cardiovascular & CNS drugs, APIs. Nutritional & healthcare products: food supplements, herbal extracts, amino acids, probiotics, functional ingredients. Pharma technology & OEM solutions: production, processing, and packaging equipment.

Amid this dynamic environment, compliance and reliability remain key to successful market access in Europe.

💡 With full REACH certification, our high-purity n-Heptane provides:

✅ Seamless entry into the European market. ✅ Trusted quality for pharmaceutical & chemical applications. ✅ Stable and reliable supply from a strong production base.

By aligning with the stringent quality and regulatory standards of the European pharmaceutical sector, we are committed to supporting innovation and long-term partnerships.

#Heptane #Pharma #REACH #Pharmaceuticals #APIs #Healthcare

Industry Transformation Creates Certainty in Uncertain Times

The European chemical industry is undergoing a historic transformation. With global giants such as Dow, INEOS, Shell, and others closing or downsizing key production facilities, the region’s supply landscape is shifting dramatically. By the end of 2027, Europe is expected to lose approximately 4.6 million tons/year of ethylene capacity, directly reshaping the downstream solvent market. Among these, n-Heptane is facing a structural supply shortage, even as demand remains resilient.

Market Restructuring and the Emerging Supply Gap

Recent plant closures highlight this dramatic shift:

Dow will shut down its ethylene cracker in Böhlen, Germany (510,000 t/y capacity) by 2027 INEOS permanently closed its phenol and acetone facilities in Gladbeck, Germany Westlake Chemical ceased operations at its Pernis, Netherlands site (150,000 t/y BPA) Celanese shut down its VAM plant in Frankfurt, Germany

These moves have pushed Europe’s chemical capacity utilization rate down to 74%, the lowest in decades. The resulting contraction in local supply capabilities has amplified the shortage of critical solvents, including n-Heptane, across pharmaceutical, coatings, adhesive, and rubber industries.

Junyuan Petroleum Group’s Advantage: Compliance + Reliability

Amid this uncertainty, Junyuan Petroleum Group provides a stable and fully compliant n-Heptane supply to European customers, backed by REACH registration and stringent quality standards.

Key Advantages:

Full REACH Compliance – Seamless market access for European clients. Stable Production Base – China-based facilities unaffected by Europe’s energy crisis. Cost Competitiveness – Significant advantage vs. European producers (EU natural gas prices are 3.3x higher than the U.S.). High Purity Guarantee – n-Heptane purity reaching 99.9%, meeting the demands of high-end applications.

Core Applications:

Pharmaceuticals – extraction solvent, crystallization medium Coatings & Inks – thinner and cleaning agent Adhesives – reaction medium and diluent Rubber Processing – solvent and extraction agent

Partnership Opportunities: Building Resilient Supply Chains

We offer European partners flexible collaboration models to ensure long-term stability and performance:

Sample Supply & Technical Dossiers – including full REACH documentation Flexible Delivery Solutions – from trial orders to long-term supply contracts Technical Support – tailored application guidance and customized solutions

Conclusion: Turning Market Disruption into Growth

The restructuring of Europe’s chemical industry is creating new opportunities in the n-Heptane supply chain. With REACH-certified, high-purity, and cost-effective products, Junyuan Petroleum Group is ready to support European customers in building reliable, sustainable, and future-ready supply networks.

Contact us today to request product details, technical documents, or samples, and secure your competitive advantage in this evolving market.

On August 28, the 17th Oil Trade Fair of the Yellow River Delta (Dongying) and Global Energy Festival 2025 officially opened. Guided by the China Petroleum Chamber of Commerce and hosted by the Dongying Petroleum Chamber of Commerce, the two-day event brought together leaders from more than 20 provincial and municipal petroleum chambers, the African Business Alliance, Cameroonian petroleum representatives, leading global petrochemical companies, and major domestic enterprises including Sinopec, CNPC, CNOOC, and Air China Petroleum. Participants also included producers of naphtha, MTBE, aromatics, and alkylates, as well as shipping, logistics, wholesale, storage, oil quality improvement companies, and key end customers.

Junyuan Petroleum Group, as Vice President Unit of the Dongying Petroleum Chamber of Commerce, actively participated in the fair to promote its products, strengthen customer relationships, and explore future industry opportunities. The event, themed “Global Energy Empowering New Industrial Energy Development,” featured market briefings, technology showcases, discussion forums, project collaborations, and trade negotiations—offering a platform for resource sharing, complementary advantages, and win-win partnerships among petrochemical enterprises.

At the exhibition, Junyuan Petroleum highlighted its full solvent portfolio, including n-Pentane, n-Hexane, Isopentane, Cyclopentane, and notably n-Heptane, which has recently obtained REACH certification. This achievement demonstrates the company’s commitment to international regulatory compliance, high-quality products, and providing clients with reliable, globally recognized solutions for chemical, pharmaceutical, and industrial applications.

Through active engagement at the fair, Junyuan’s team gained insight into the latest industry trends, deepened connections with clients, and laid a solid foundation for expanding market reach. Moving forward, the team will continue to integrate resources, enhance collaboration with partners, and drive business growth to a new level.

China Revises Tariff Code for n-Heptane—Effective from 2025 for International Trade and Customs Declarations

As of 2025, the official HS code for n-Heptane (正庚烷) in China has been updated to 2901109000, replacing previous classifications. This change aligns with China’s ongoing efforts to streamline chemical import/export procedures and improve tariff data accuracy. Exporters, importers, and customs brokers dealing with n-Heptane must take note of this update to ensure smooth customs clearance and compliance in the new year.

HS Code Update 2025: New Customs Classification for n-Heptane

Starting in 2025, China has officially updated the HS code for n-Heptane (正庚烷) to 2901109000. This revision reflects the nation’s broader initiative to standardize customs procedures and enhance trade transparency for chemical products.

n-Heptane, a high-purity hydrocarbon solvent widely used in pharmaceutical synthesis, electronics cleaning, and laboratory research, was previously grouped under broader aliphatic hydrocarbon codes. The new classification under 2901109000 provides greater specificity, reducing ambiguity during customs declarations.

Key Implications for Exporters and Importers:

• Customs Declaration Compliance: All declarations for n-Heptane exports or imports must now reference the updated HS code 2901109000.

• Documentation Updates: Relevant shipping and trade documentation, including invoices, packing lists, and certificates of analysis, should reflect the new code.

• Tariff Adjustment Readiness: Businesses should recheck applicable tariffs or trade agreements tied to this new code to ensure accurate duty calculations.

• System Integration: Companies using ERP or logistics systems must update their product HS code databases accordingly.

This change reinforces the importance of staying current with evolving customs classifications, especially for chemical exporters. Failure to comply with updated HS codes may result in delayed shipments, penalties, or even rejections at ports.

For those exporting high-purity n-Heptane (99%) or technical-grade variants, we recommend verifying with local customs agents or trade authorities to ensure proper implementation.

Keywords:

n-Heptane, 正庚烷, HS Code 2901109000, 2025 Customs Update, Chemical Exports China, Heptane Tariff Code, Chemical HS Classification, Import Export Compliance, Pharmaceutical Solvents, Hydrocarbon Solvent Trade

As of April 28, 2025, the domestic price for 99% purity n-Heptane in China remains stable at RMB 15,900 per metric ton, approximately USD 2,170 per metric ton based on the current exchange rate (1 USD ≈ 7.327 RMB).

Following a sharp price adjustment around mid-April, the market has entered a period of stability, with no fluctuations recorded over the past two weeks. For global procurement teams, this price consistency provides a more predictable environment after recent volatility.

The stable trend is largely supported by balanced domestic supply and steady demand from key downstream sectors such as pharmaceuticals, adhesives, and industrial solvents. Buyers worldwide are advised to continue monitoring market conditions closely, as potential shifts in feedstock availability or production rates could impact export offers in the coming months.

With China being a major supplier of high-purity n-Heptane, the current stability offers an opportunity for strategic procurement planning and inventory management for Q2 2025.

n-Heptane, 99% Purity, Global Procurement, Market Price, Price Stability, China Exports, Solvent Market, April 2025, USD Price, RMB Price

This analysis focuses on the price trend of 99% pure n-Heptane in the Central China region from April 14 to April 25, 2025. The data reveals a significant price change within this period.

On April 14, the price of 99% n-Heptane was relatively high in the Central China market. However, the price began to decline soon after, marking a noticeable and continuous downward trend. By April 25, the price stabilized at RMB 15,200/ton (~USD 2,080/ton), with no further changes on that day, showing a price fluctuation of 0.00%.

For purchasers, this price trend highlights several key points to consider. First, whether this downward trend is temporary or indicative of a long-term market shift is crucial. If the decline is only a short-term adjustment, prices may stabilize or even increase later. In this case, excessive stockpiling at the current low prices could lead to higher costs if prices rebound. On the other hand, if the price drop is due to fundamental industry changes, such as increased raw material supply or heightened market competition, buyers could take advantage of this opportunity to increase their purchasing volume within reasonable limits to lower their average procurement costs.

The supply side dynamics are also essential for purchasers to monitor closely. If new n-Heptane production facilities are launched or existing companies expand production, market supply could significantly increase. If demand remains stable or grows slowly, prices may continue to face downward pressure. Conversely, if production plants shut down or face maintenance issues, leading to reduced supply, prices could stabilize or rebound. Therefore, purchasers should stay informed about supply-side changes through communication with suppliers and industry news.

Additionally, the availability of substitutes should not be overlooked. In the chemical raw materials market, multiple alternatives with similar functions often exist. If the price of n-Heptane continues to fall, its relative cost-effectiveness may change. If comparable substitutes with better pricing emerge, purchasers may need to reassess their procurement strategies or even consider adjusting product formulas to incorporate these substitutes and reduce costs.

Industry policies and the development of upstream and downstream industries also influence n-Heptane prices. For instance, stricter environmental regulations could limit the production of n-Heptane, impacting both supply and prices. Similarly, changes in the demand from n-Heptane’s downstream industries will directly reflect on its price. Purchasers should stay attuned to industry policies and the trends in upstream and downstream industries to make more informed purchasing decisions in a complex market environment.

In summary, the price of 99% n-Heptane in Central China decreased in April 2025 and stabilized by the end of the month. In future procurement activities, buyers should carefully consider factors such as the su