Tag Pharmaceutical solvent

High-purity n-Heptane in sealed laboratory glassware labeled with REACH and CLP hazard pictograms, placed on a compliant chemical safety workstation under bright light.

n-Heptane (CAS 142-82-5, EC 205-563-8) – REACH-Registered, Fully Compliant Hydrocarbon Solvent for European Industry

n-Heptane Overview

n-Heptane (CAS No. 142-82-5, EC No. 205-563-8) is a straight-chain hydrocarbon (C₇H₁₆) recognized throughout the European regulatory framework as a key industrial solvent. It is classified under the CLP Regulation Annex VI and officially registered in ECHA’s Registered Substances Database, confirming its full REACH compliance for import and use across the European Economic Area (EEA) at volumes exceeding 1,000 tonnes per year.


Substance Names and Other Identifiers

Main substance name:

  • n-Heptane

Other common names and synonyms:

  • Heptane
  • Heptan
  • Heptanen
  • Dipropylmethane
  • Dipropyl methane
  • Heptyl hydride
  • Normal heptane
  • Heptane (all isomers)
  • Heptane [99.0% for HPLC Solvent]
  • Heptane [and isomers]
  • n-Heptano
  • Gettysolve-C
  • Skellysolve C
  • Eptani
  • Hydrocarbon solvents

Regulatory process names:

  • Heptane
  • Heptane; n-Heptane
  • n-Heptane
  • heptane/n-heptane

Translated names (examples):

  • Heptan, n-Heptan (German)
  • Heptan, N-heptan (Romanian)

Trade names:

  • Heptane
  • n-Heptane

Identifiers:

  • CAS number: 142-82-5
  • EC number: 205-563-8
  • Index number: 601-008-00-2
  • Other CAS numbers (legacy or related): 44607-13-8, 8031-33-2

IUPAC names:

  • Dipropylmethane
  • n-Heptane

Regulatory and Directive references:
n-Heptane is listed under multiple EU regulations and directives, including:

General Product Safety Regulation – Hazardous Substances

REACH Registration Dossier

EC Inventory

C&L Inventory

Pre-registration process

Aerosols Directive – Flammable Contents

Chemical Agents Directive (CAD) – Hazardous Agents

Ambient Air Quality Directive, Annex X – Ozone Precursor Substances

Occupational Exposure Limits (OELVs) – Indicative List

Construction Products Regulation – Hazardous Substances (Annex I & Art. 6)

EU Ecolabel Regulation – Hazardous Substance Restrictions

Medical Devices Directives and Regulations – Hazardous Substances

Pressure Equipment Directive – Group 1 Fluids

Waste Framework Directive – Annex III Hazardous Properties

Fertiliser Regulation, Annex I, E.3 – Chelating/Complexing Agents

Due to its extensive industrial and scientific use, n-Heptane is known under a wide range of regulatory, IUPAC, and trade names across different European legislations and databases.

Regulatory Process Names:
Dipropyl Methane, Eptani, Gettysolve-C, Heptan, Heptane, Heptanen, Heptyl Hydride, n-Heptane, Skellysolve C

Translated Names (EU languages):

  • Heptan / n-Heptan (DE) – German
  • Heptan / N-heptan (RO) – Romanian

IUPAC and Technical Names:
Dipropylmethane, n-Heptane, Heptane (all isomers), Heptane [99.0% for HPLC Solvent], Normal Heptane, Hydrocarbon Solvent

Trade Names:
Heptane, n-Heptane, Gettysolve-C, Skellysolve C

Identifiers:

  • CAS Number: 142-82-5 (Main)
  • EC Number: 205-563-8
  • Index Number (CLP): 601-008-00-2
  • Other CAS Numbers: 44607-13-8, 8031-33-2
  • Molecular Formula: C₇H₁₆

These identifiers appear consistently across EINECS, C&L Inventory, REACH Pre-registration, and multiple EU regulatory annexes, ensuring full traceability and transparency in supply.


Regulatory Framework and Compliance

n-Heptane is explicitly listed under numerous European chemical and environmental legislations, highlighting its regulated yet accepted status in industrial and laboratory operations:

  • REACH Regulation – Registered substance (≥1000 tpa)
  • CLP Regulation Annex VI – Harmonized classification & labeling
  • Seveso III Directive Annex I – Industrial accident prevention
  • Waste Framework Directive Annex III – Hazardous properties
  • Occupational Exposure Limits (OELs) – Indicative EU OELVs
  • Construction Products Regulation (Annex I & Art.6(5))
  • EU Ecolabels & Environmental Policy Framework Directive
  • Medical Devices Regulation / Directive (Hazardous Substances)
  • General Product Safety Regulation & Workplace Safety Directive

This extensive inclusion across directives confirms that n-Heptane is both recognized and regulated for controlled industrial use, making it an ideal choice for European manufacturers seeking long-term compliant sourcing.


Applications Across European Industries

n-Heptane’s versatility has established it as a critical raw material and process solvent in:

  • Pharmaceutical manufacturing – extraction, crystallization, and purification
  • Laboratories – high-purity analytical use (HPLC, GC)
  • Coatings and adhesives – solvent and viscosity control
  • Automotive and fuel industry – reference standard for octane rating
  • Cleaning and degreasing agents – controlled volatility applications

Safety and Environmental Management

Classified as a highly flammable liquid (H225), skin irritant (H315), and toxic to aquatic life (H410), n-Heptane must be handled with professional containment, proper labeling, and full compliance to the GHS/CLP system.
Manufacturers provide complete Safety Data Sheets (SDS) and Guidance on Safe Use, aligned with the Chemical Agents Directive (CAD) and Pressure Equipment Directive.


Why Choose Our n-Heptane

Fully REACH-registered and CLP compliant
High-purity grades (up to 99%) for pharmaceutical and analytical use
Stable European supply in ISO tanks or drums
Complete documentation package (SDS, COA, technical data)
Proven compliance with EU industrial, medical, and environmental standards

Our n-Heptane product line delivers consistency, safety, and full regulatory transparency for European customers in pharmaceuticals, R&D, and specialty chemicals manufacturing.

For technical details, safety classifications, and compliance information, professionals can refer to the European Chemicals Agency (ECHA) official database:
https://echa.europa.eu/substance-information/-/substanceinfo/100.014.194

This authoritative link strengthens data transparency and helps industry experts verify REACH registration status, CLP classification, and exposure limits of n-Heptane (CAS 142-82-5) under European regulatory frameworks.

Our factory of high purity n-Heptane

Global Leading n-Heptane Brand, REACH Certified Products Enter European Market in 2025

With the rapid development of European industry and increasingly strict environmental standards, the demand for high-quality n-Heptane continues to rise. Starting in 2025, Junyuan Petroleum Group, a global leading n-Heptane producer, has officially entered the European market with its REACH certified products, providing reliable, high-purity, and eco-friendly solutions for the pharmaceutical, electronics, coatings, and chemical industries.

Market Opportunities and Trends

The European n-Heptane market is growing rapidly, particularly in pharmaceuticals, automotive, coatings, and electronics, where high-purity (≥99%) and eco-friendly n-Heptane is increasingly required. Despite limited local production and closures of major facilities, Junyuan Petroleum Group’s entry effectively addresses supply gaps, offering stable supply to customers.

Key Applications

  • Pharmaceuticals: High-purity n-Heptane is used in drug synthesis, formulation, and chromatography purification.
  • Automotive: Solvent for coatings, adhesives, and fuel additives.
  • Coatings & Paints: Quick evaporation and strong solvency ensure smooth surfaces.
  • Chemicals & Electronics: Used in specialty chemicals, lubricants, and component cleaning.
  • Food & Beverage: Extraction and purification of natural flavors and essential oils.

European Market Highlights

  • Western Europe Dominance: Germany, France, and the UK have stable industrial demand.
  • Emerging Eastern Europe: Poland, Hungary, and the Czech Republic show high growth potential.
  • Sustainability Focus: REACH certification is a key market entry requirement, and Europe emphasizes green chemistry.

Strategic Advantage of Junyuan Petroleum Group

Through global production and mature technology, Junyuan Petroleum Group provides high-purity, eco-friendly, and stable supply of n-Heptane, meeting the strict standards of European clients. With full REACH certification since 2025, the n-Heptane market in Europe is poised for comprehensive growth.