Sodium methoxide is a sodium alkoxide. Its reaction with unactivated aryl bromides in the presence of copper catalyst under various reaction conditions has been studied. It reacts with aryl halides in the presence of a palladium catalyst in DMF to afford arenes.

reagent grade, 95%, powder
Synonym: Sodium methylate

CAS Number 124-41-4
Linear Formula NaOCH3
Molecular Weight 54.02
Beilstein/REAXYS Number 3592982
EC Number 204-699-5
MDL number MFCD00012179
PubChem Substance ID 24850111
NACRES NA.21

SDS – Safety Information

Symbol 
  GHS02,GHS05,GHS07
Signal word 
Danger
Hazard statements 
H228 – H251 – H290 – H302 – H314
Precautionary statements 
P210 – P235 – P260 – P280 – P303 + P361 + P353 – P305 + P351 + P338
Supplemental Hazard Statements 
EUH014
Personal Protective Equipment 
Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR 
UN 1431 4.2(8) / PGII
WGK Germany 
WGK 2
Flash Point(F) 
91.4 °F – closed cup
Flash Point(C) 
33 °C – closed cup

Product Name:                             Sodium methoxide

reagent grade, 95 %, powder

Product Number:                         2101251226

Batch Number:                             LX202101251155

Brand:                                          Junyuan Petroleum Group

CAS Number:                               124-41-4

Formula:                                      NaOCH3

Formula Weight:                          54.02

Quality Release Date:                   25 JAN 2021

Recommended Retest Date:        JAN 2022

TESTSPECIFICATIONRESULT
APPEARANCE (COLOR)WHITEWHITE
APPEARANCE (FORM)POWDERPOWDER
TITRATION (T) HCL 0.1M≥94.5 %98.9 %
REMARKS ON TITRATIONTOTAL NA2CO3 AND NAOH IMPURITIES ≤5.5 %1.0 %
INFRARED SPECTRUMCONFORMS TO STRUCTURECONFORMS

Sodium Methoxide

Chemical Formula of Sodium Methoxide: NaOCH3

Other names: Sodium Methylate, Sodium Salt

Appearance: White Crystalline Powder

Uses of Sodium Methoxide:

  1. Organic Chemistry: it is used in the synthesis of several chemical compounds such as pharmaceuticals and agrichemicals. It is also used as a base in aldol condensations and dehydrohalogenations. It acts as a nucleophile in the manufacturing of methyl ethers.
  2. Pharmaceutical Industry: it is used in the manufacture of substances like Vitamins A1 and B1, Trimethoprim, Sulfadiazine, Sulfadoxine, Sulfamethoxypyridazine
    Biodiesel Industry: it is used as a catalyst for producing fatty acid methyl esters or FAMEs.
  3. It can be used for processing edible oils and fats and also in the preparation of some other chemical products.
  4. It can be used as an edible catalyst as well as an analytical reagent.
  5. It can be used in production of pesticides.
  6. Sodium methoxide has been used in the preparation of 5-(3-azidopropyl) uridine. It may be used in the synthesis of methyl 2-cyano-lup-3-hydroxy-2-en-28-oate (CN-BA), a 2-cyano derivative of betulinic acid (BA).
  7. Sodium methoxide may be used as an alkali catalyst for the production of fatty acid methyl esters (biodiesel) from vegetable oils via transesterification.