Polyurethane foam is widely used in construction, refrigeration, piping and other fields due to its low density, good thermal insulation, low water absorption, low toxicity, and good processability. The blowing agent is an important auxiliary agent for the production of polyurethane foam plastics. Since the second-generation blowing agent HCFC-141b has an ODP value of 0.11 and a GWP value of 725, it has a great impact on the ozone layer and the greenhouse effect, so it can only be used as a transitional agent. use of sex substitutes. According to China’s polyurethane foam industry HCFC-141b phase-out plan (second phase), the polyurethane foam industry will gradually reduce HCFC-141b consumption based on the results achieved in the first phase, and will achieve industry-wide phase-out by the end of 2025. At present, the commonly used substitutes for HCFC-141b blowing agent mainly include pentane, water, hydrofluorocarbon (HFC), liquid carbon dioxide, hydrofluoroolefin (HFO) and methyl formate. Among them, pentane is widely used due to its advantages of environmental protection, low price, and easy availability. However, pentane is flammable and explosive, and is a dangerous chemical. The use of this kind of blowing agent requires safety renovation of production equipment and workshops. Although the initial investment of pentane foaming replacement technology is relatively high, in the long run, the comprehensive economic benefits are obvious, and it is an ideal substitute for HCFC-141b.