Preparation Method:
Add 100g (1.53mol) of zinc amalgam, 250ml of concentrated hydrochloric acid and 50ml of water into the reaction bottle equipped with stirrer, reflux condenser and vent pipe (extending into the bottom of the bottle), add 40g (0.35mol) of octanone-2 (2) under stirring, and slowly inject hydrogen chloride gas. If the reaction is too violent, the hydrogen chloride gas can be suspended. After 2-3H, most of the zinc amalgam reaction was completed, hydrogen chloride was stopped and placed overnight. Remove the agitator and change to steam distillation unit for steam distillation until the distillate is transparent. The upper oil layer was separated, washed twice with distilled water, fractionated after drying with anhydrous sodium sulfate, and the fraction at 124-126 ℃ was collected to obtain 26G octane (1) with a yield of 58%.
Product Name: n-Octane
Product Properties and Uses: pharmaceutical intermediates;
Category: pharmaceutical intermediates;
