Solid Sodium Methoxide

Solid Sodium Methoxide
Molecular formula: CH3NaO
Molecular Weight: 54.02
CAS: 124-41-4
Molecular Formula: CH3NaO
Density: 54.02
CAS: 124-41-4
Recommended and restricted uses of products: It is mainly used in pharmaceutical industry and organic synthesis as condensing agent, chemical reagent, catalyst for edible oil treatment, etc.

Potential Health Effects
Eye: Causes eye burns. May cause blindness. Lachrymator (substance which increases the flow of tears).
Skin: Causes skin burns. May be harmful if absorbed through the skin.
Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Causes gastrointestinal tract burns. May be harmful if swallowed.
Inhalation: Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Adverse reproductive effects have been reported in animals. Laboratory experiments have resulted in mutagenic effects.

Handling: Do not allow water to get into the container because of violent reaction. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Keep away from heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area. Water free area. Store under nitrogen.

Physical State: Powder
Appearance: yellow – white
Odor: none reported
pH: 13 (5g/L aq.sol.(20°C))
Vapor Pressure: 50 mm Hg @ 20 deg C
Vapor Density: Not available.
Evaporation Rate:Not applicable.
Viscosity: Not applicable.
Boiling Point: decomposes
Freezing/Melting Point:126 deg C
Decomposition Temperature:Not available.
Solubility: Reacts.
Specific Gravity/Density:Not available.
Molecular Formula:CH3NaO
Molecular Weight:54.02

Chemical Stability: Unstable in air. Reacts violently with water.
Conditions to Avoid: Incompatible materials, ignition sources, dust generation, exposure to air, excess heat, temperatures above 65°C, exposure to moist air or water.
Incompatibilities with Other Materials: Chlorinated solvents, metals, strong oxidizing agents, acids.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, sodium oxide.
Hazardous Polymerization: Has not been reported

RTECS#:
CAS# 124-41-4: PC3570000
CAS# 497-19-8: VZ4050000
CAS# 1310-73-2: WB4900000
LD50/LC50:
CAS# 124-41-4:
Oral, rat: LD50 = 2037 mg/kg;
.

CAS# 497-19-8:
Draize test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, eye: 50 mg Severe;
Draize test, rabbit, skin: 500 mg/24H Mild;
Inhalation, mouse: LC50 = 1200 mg/m3/2H;
Inhalation, rat: LC50 = 2300 mg/m3/2H;
Oral, mouse: LD50 = 6600 mg/kg;
Oral, mouse: LD50 = 6600 mg/kg;
Oral, rat: LD50 = 4090 mg/kg;
.
CAS# 1310-73-2:
Draize test, rabbit, eye: 400 ug Mild;
Draize test, rabbit, eye: 1% Severe;
Draize test, rabbit, eye: 50 ug/24H Severe;
Draize test, rabbit, eye: 1 mg/24H Severe;
Draize test, rabbit, skin: 500 mg/24H Severe;
.
Oral, rat: LD50 = 2037 mg/kg.; Oral mouse: LD50 = 200 mg/kg.; Dermal: LD50 = 500-1000 mg/kg.
Carcinogenicity:
CAS# 124-41-4: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 497-19-8: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 1310-73-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information found
Teratogenicity: No information found
Reproductive Effects: Adverse reproductive effects have occurred in experimental animals.
Mutagenicity: Mutagenic effects have occurred in experimental animals.
Neurotoxicity: No information found
Other Studies:

Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: Do not empty into drains.

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Hazard characteristics analysis of solid sodium methoxide
1.1 transportation hazards of solid sodium methoxide
In the United Nations Recommendation on the transport of dangerous goods (hereinafter referred to as the “recommendation”), dangerous goods are divided into explosives, gases (including flammable gases, toxic gases, non flammable and non-toxic gases), flammable liquids, flammable solids (including substances prone to spontaneous combustion and substances that emit flammable gases in contact with water) according to the risk or the most important risk during the transport of dangerous goods Oxidizing substances and organic peroxides, toxic and infectious substances, radioactive substances, corrosive substances, miscellaneous hazardous substances and articles (including substances harmful to the environment).
According to the dangerous degree of the contents, the packaging of dangerous goods is divided into three packaging categories: the most dangerous substances are packed in class I packaging; Medium hazardous substances shall be packed in class II packaging; Mild hazardous substances shall be packed in class III packaging. In the “list of dangerous goods” in the proposal, the UN number of solid sodium methoxide is un1431, the main risk is class 4.2 self heating substance, the secondary risk is class 8 corrosive substance and class II packaging. According to the provisions in 2.0.3.3 “list of hazard sequence” of the proposal, when the dangerous goods have class 4.2 hazard characteristics and class II packaging, and also have class 8 corrosive hazard and class II or III packaging, the overall hazard of class 4.2 shall be placed before class 8, that is, the goods have double hazard characteristics during transportation. The self heating danger of solid sodium methoxide is a process in which the substance gradually reacts with oxygen in the air to produce heat. If the rate of heat generation exceeds the rate of heat loss, the temperature of the material will rise, and after a period of induction period, it can spontaneously catch fire or spontaneous combustion. Class II packaging is adopted for the transportation of solid sodium methoxide, that is, 25mm cube sample is tested at 140 ℃ in the self heating hazard test. When the external ambient temperature is 140 ℃, the internal temperature of the sample can exceed the ambient temperature by 60 ℃ to more than 200 ℃, which is the most dangerous self heating substance.
The corrosive hazard of solid sodium methoxide refers to that it is very easy to react with water to form strong caustic sodium hydroxide, which will cause skin corrosion if exposed to human body. The reaction equation is: H2O + CH3ONa → CH3OH + NaOH. Skin corrosion refers to irreversible damage to the skin. The corrosion reaction was characterized by ulceration, bleeding and bloody scab, and at the end of the observation period of 14 days, the skin, complete hair loss area and scab faded due to bleaching. In the experiment, if a substance causes skin damage to at least one test animal after contacting with the skin for up to 4 hours, that is, visible epidermal and dermal necrosis, the substance is corrosive to the skin.
From the above dangerous characteristics of sodium methoxide, it can be seen that the use of packaging containing less goods to prevent heat accumulation, avoid contact with air and moisture, and maintain the sealing of its packaging is the key factor to ensure transportation safety.
1.2 GHS classification of solid sodium methoxide
The United Nations globally harmonized system of classification and labelling of chemicals (hereinafter referred to as GHS) is a set of chemical classification and labelling system, which is used to unify the classification and labelling of chemicals in different countries and regions around the world. It is jointly prepared and formulated by the organization for economic cooperation and development (OECD), the International Labour Organization and the GHS subcommittee under the United Nations Economic Commission for Europe. The first edition was officially published in December 2002. After further modification and improvement by experts from various countries, the latest version is the sixth revised version published in 2015. GHS focuses on the whole life cycle of chemicals such as production, transportation, sales and use. The classification of chemicals includes 17 physical hazards, 10 health hazards and 2 environmental hazards.
When formulating the 2015 edition of the catalogue, the State Administration of work safety referred to some internationally widely used GHS classification databases, including:
Annex 6 of the regulation “classification, labelling and packaging of chemicals” (CLP) formulated by the European Chemical Agency lists the GHS classification of more than 4000 common hazardous chemicals. The classification of solid sodium methoxide is: self heating substances and mixtures, category 1, skin corrosion / irritation category 1b;
The “hazardous substances and new organics” (HSNO) regulations database developed by the New Zealand Environmental Protection Agency lists the GHS classification of more than 5400 common hazardous chemicals. The classification of solid sodium methoxide is: self heating substances and mixtures category 1, acute toxicity (oral) category 4, skin corrosion / irritation category 1b, and serious eye injury / eye irritation category 1.
The GHS classification database developed by the National Institute of technology and evaluation (nite) of Japan lists the GHS classification of more than 3000 common hazardous chemicals. The classification of solid sodium methoxide is: flammable solid category 1, self heating substances and mixtures category 1, acute toxicity (oral) category 4, skin corrosion / irritation category 1, severe eye injury / eye irritation category 1, Specific target organ toxicity – single exposure category 3 (anesthetic effects).
Based on the classification of solid sodium methoxide in the above three databases, solid sodium methoxide is classified into self heating substances and mixtures category 1, skin corrosion / irritation category 1b and severe eye injury / eye irritation category 1 in the “classification information table of hazardous chemicals” of the catalogue 2015 edition. According to the requirements of the sixth revision of GHS, the hazard publicity label of solid sodium methoxide is shown in Table 1 (where hxxx is the code of GHS hazard statement and pxxx is the code of GHS prevention statement).